Unleash the Power of Autophagy for Longevity and Long-Term Health
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Unleash the Power of Autophagy for Longevity and Long-Term Health

By Max Cerquetti May 02, 2023

Understanding Autophagy and Its Benefits


The word "autophagy" is derived from Greek, translating to "self-eating." Autophagy is a catabolic process that breaks down and recycles cellular components, helping to create new cells. This self-regulation mechanism, also known as homeostasis, plays a vital role in maintaining a healthy balance within the body.

During autophagy, the cytoplasm – a jelly-like substance outside the cell's nucleus – and small structures called organelles are removed from the cell and recycled. This process is essential for removing cells that are no longer functioning properly. Disruption of autophagy is linked to several diseases, particularly neurodegenerative disorders like Parkinson's.


Unleash the Power of Autophagy for Longevity and Long-Term Health_Nutriop-Longevity


The Autophagy Process Explained

Autophagy is triggered when a cell lacks sufficient nutrients. The process consists of four stages:

1. Sequestration

A double-membrane structure called the phagophore surrounds and encloses cytoplasm and organelles. The phagophore then transforms into an organelle known as the autophagosome.

2. Fusion

Autophagosomes merge with endosomes to form amphisomes, which are then able to fuse with lysosomes.

3. Degradation

Once fused with a lysosome, degradation occurs as hydrolase enzymes break down the materials initially enclosed by the autophagosome. The resulting structure is called an autophagolysosome or autolysosome.

4. Reuse

Following complete degradation, amino acids are released into the cellular fluids and can be reused by new cells.

These amino acids are utilized in the TCA cycle (also known as the citric acid cycle), a series of chemical reactions that serve as the primary driver for cell respiration. NAD+, one of our best-selling supplements, plays a crucial role in most of the TCA cycle reactions.

The Different Types of Autophagy

There are three types of autophagy, each with distinct features:

1. Macro Autophagy

This refers to the general autophagy process outlined above.

2. Micro Autophagy

This process also engulfs and degrades different cell structures but does not involve a phagophore during sequestration. Instead, a lysosome directly engulfs cellular contents, breaking them down into amino acids for recycling.

3. Chaperone-mediated Autophagy

This selective process targets proteins for degradation, with chaperone proteins aiding the translocation of degradable proteins along lysosome membranes.

Autophagy's Role in Anti-Aging and Longevity

Autophagy is a stress response (triggered by cell starvation) that rejuvenates cells, making them more energy-efficient and resilient to damage. Research indicates that activating autophagy suppresses the accumulation of age-associated cellular defects, significantly improving the metabolic efficiency of targeted cells.

Autophagy can also target malfunctioning mitochondria that produce harmful reactive oxygen species (ROS), contributing to cell degradation – a process known as mitophagy.

Studies have demonstrated that inducing autophagy extends the lifespan of mice.

Additional Benefits of Autophagy

Beyond anti-aging, autophagy plays a key role in preventing age-related diseases. It removes toxic proteins associated with neurodegenerative disorders such as Alzheimer's and Parkinson's disease.

Autophagy can also prevent malfunctioning cells from multiplying and forming the basis for cancer by breaking down corrupted cellular structures into amino acids. While more research is needed, many medical professionals believe autophagy is vital in the prevention and treatment of cancer, as it increases genomic stability.

In summary, autophagy offers numerous known or presumed benefits, including:

- Regulating mitochondria in cells, enhancing energy production.
- Protecting the immune and nervous systems.
- Preventing metabolic stress.
- Potentially safeguarding against heart disease and cognitive decline by promoting new cell growth, especially in the brain and heart.
- Preventing inflammatory diseases such as Crohn's by restoring the gut lining, thereby improving digestive function.
- Stabilizing DNA and protecting our genes.
- Possibly preventing and treating various cancer types, as it is believed to be a tumor suppressor.
- Slowing down aging by rejuvenating the body with new cells without increasing energy demands.

Ways to Induce Autophagy

Considering the numerous health benefits that extend beyond anti-aging, you might wonder how to trigger autophagy in your body. Autophagy is a stress response, so mild stress that doesn't significantly damage the body can be beneficial in activating autophagy. Several daily measures have been identified to help induce autophagy:

1. Nutrition

Resveratrol and its more potent and bioavailable relative, pterostilbene, have been found to induce autophagy.
Curcumin from turmeric and 6-Shogaol from ginger have been shown to activate autophagy.
The active ingredient in cinnamon has also been found to trigger autophagy.
Coffee and an active ingredient in green tea have been proven to increase autophagy in mice.

2. Exercise

Exercise has been shown to induce autophagy in peripheral muscle and brain tissue in mice. Another study suggests that physical exercise may trigger autophagy in organs involved in metabolic regulation (e.g., liver, adrenal glands, and thyroids). So, in addition to other health benefits, cardiovascular exercise is an excellent way to expose cells to "healthy" stress and autophagy.

3. Intermittent Fasting and Caloric Restrictions

Fasting has various benefits, including decreasing inflammation levels, boosting brain function, and increasing HGH secretion. These benefits might be possible, not directly through fasting, but as a side effect of autophagy. Studies on mice have shown that autophagy can be induced through intermittent fasting and caloric restriction. Thus, frequent short-term fasting may be a viable method to combat neurological conditions and cancer growth.

4. Adequate Sleep

Autophagy is also triggered during sleep. The circadian rhythm, which is directly related to anti-aging, controls our sleep cycle and is linked to autophagy. Studies have shown that lack of REM sleep may negatively affect autophagy in neurons, leading to altered brain function. Disrupting sleep in mice models also disrupted their autophagy protein transmission.

By understanding the benefits of autophagy and incorporating these practices into your daily routine, you can promote longevity and long-term health.

Supplements to Support Autophagy

In addition to the aforementioned lifestyle changes, certain supplements may also support autophagy. Some of these supplements include:

1. NAD+ (Nicotinamide Adenine Dinucleotide)

NAD+ is a coenzyme that plays a vital role in many reactions within the TCA (citric acid) cycle, a series of chemical reactions central to cellular respiration. By supplementing with NAD+, you can help maintain the efficiency of the TCA cycle, thereby supporting autophagy and promoting longevity.

2. Berberine

Berberine is a natural compound found in various plants, such as goldenseal, barberry, and Oregon grape. It has been shown to activate an enzyme called AMP-activated protein kinase (AMPK), which plays a crucial role in inducing autophagy.

3. Quercetin

Quercetin is a flavonoid found in various fruits, vegetables, and grains. It has been shown to have anti-inflammatory, antioxidant, and anti-cancer properties. Some studies suggest that quercetin can help induce autophagy, offering potential benefits for longevity and overall health.

4. Sulforaphane

Sulforaphane is a compound found in cruciferous vegetables such as broccoli, cabbage, and kale. It has been shown to activate the NRF2 pathway, which plays a critical role in cellular defense mechanisms, including autophagy.

In conclusion, autophagy is an essential process that contributes to overall health, longevity, and the prevention of age-related diseases. By adopting a lifestyle that includes a balanced diet, regular exercise, intermittent fasting, adequate sleep, and the use of targeted supplements, you can support autophagy and optimize your body's natural rejuvenation processes.





[i] https://www.ncbi.nlm.nih.gov/pubmed/25654554

[ii] https://www.ncbi.nlm.nih.gov/pubmed/24079773

[iii] https://pubmed.ncbi.nlm.nih.gov/23939249/

[iv] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388596/

[v] https://www.ncbi.nlm.nih.gov/pubmed/25068516

[vi] https://www.sciencedirect.com/science/article/pii/S1021949816301855

[vii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028754/


[viii] https://pubmed.ncbi.nlm.nih.gov/19799425


[ix] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855773/

[x] https://www.ncbi.nlm.nih.gov/pubmed/24769862

[xi] https://www.ncbi.nlm.nih.gov/pubmed/24489859

[xii] https://pubmed.ncbi.nlm.nih.gov/22892563/

[xiii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463459/

[xiv] https://www.ncbi.nlm.nih.gov/pubmed/23755298

[xv] https://www.ncbi.nlm.nih.gov/pubmed/8719443


[xvi] https://pubmed.ncbi.nlm.nih.gov/27411589/


[xvii] https://www.ncbi.nlm.nih.gov/pubmed/20534972 


[xviii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389582/


[xix] https://www.sciencedirect.com/science/article/abs/pii/S1389945719301522


[xx] https://www.ncbi.nlm.nih.gov/pubmed/27078501

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