Nutriop Longevity®·Senolytic Polyphenol
Move better. Recover faster. Age slower.
Advanced Cellular Defense System
"I'm 58 and just PRed my deadlift. My 30-year-old gym buddy asked for my secret. I just smiled."
"Three months in: hiking with grandkids, no ibuprofen needed. Wife thinks I'm having a midlife crisis. Nope, just found my second wind."
Synergistic Polyphenol Complex Verification
Resveratrol PLUS combines trans-resveratrol, fisetin, quercetin, liposomal curcumin, and piperine — five researched compounds that work across different cellular pathways to support how your body defends, recovers, and ages.
You used to finish a hard workout, sleep it off, and wake up fine. A stressful week at work wouldn't follow you into the weekend. Your body handled it.
Something shifted. Not all at once — gradually. Recovery takes longer. Stiffness shows up uninvited. That general soreness after physical effort sticks around an extra day or two. And you can feel the difference between how your body responds to stress now versus five or ten years ago.
What's behind this? Partly, it's that your body's natural cellular maintenance is slowing down. Damaged cells that should be cleared away start accumulating instead — scientists call these "senescent cells." They don't function properly, but they don't get removed either. They sit there, secreting inflammatory signals that affect the cells around them.
At the same time, your antioxidant defences weaken. Oxidative stress builds up faster than your body can neutralise it. The inflammatory response that used to help you heal starts running a little too hot, a little too often.
None of this is irreversible. But it is specific. And addressing it requires more than a single ingredient.
Most polyphenol supplements give you a single compound — resveratrol, or quercetin, or curcumin — and call it a day. The research on each of these molecules is real. But they work through different mechanisms, and your body's cellular defence system isn't a single pathway. It's a network. Here's the thinking behind Resveratrol PLUS:
Resveratrol activates SIRT1 — a protein sometimes called the "longevity gene" because of its role in cellular protection and DNA repair. It's one of the most-studied longevity molecules in existence.
Fisetin is a senolytic — it targets senescent cells (the "zombie cells" that have stopped functioning but won't die). Clearing these cells is one of the most exciting areas in ageing research right now.
Quercetin supports healthy inflammatory response and — critically — enhances the absorption and activity of resveratrol. It's not just a second polyphenol; it's a multiplier for the first one.
Curcumin is a potent antioxidant with research supporting its role in managing oxidative stress and inflammation. The challenge has always been absorption — which is why we use a liposomal form.
Piperine doesn't do much on its own. But it dramatically increases the bioavailability of curcumin (by up to 2,000% in some studies) and supports the absorption of other compounds in the formula.
These aren't five random ingredients in a capsule. They're five compounds chosen because they address different parts of the same problem — and because they make each other work better.
1,310mg per serving. Five active compounds. Zero fillers. Here's what each one does, where it comes from, and why it's dosed the way it is.
Resveratrol is the molecule that started the longevity polyphenol conversation. We use 99% pure trans-resveratrol, the biologically active form. Many supplements use a mix of cis and trans isomers, but only the trans-form effectively activates SIRT1. Ours is sourced from Japanese Knotweed, which naturally contains far higher concentrations than grape sources — typically 99% versus 5-10% from grape extracts. At 500mg per serving, this is the same dose used in published human studies.
Quercetin is a flavonoid found in onions, apples, and berries. In this formula, quercetin plays a dual role: it provides its own antioxidant benefits while enhancing resveratrol's bioavailability and metabolic activity. Research has shown that quercetin inhibits the enzymes that break down resveratrol in your gut, meaning more of the resveratrol you take actually reaches your cells intact.
Fisetin is the reason this product is categorised as a "senolytic polyphenol" rather than just another antioxidant blend. Senescent cells accumulate in your tissues as you age, secreting inflammatory compounds (the SASP) that affect healthy cells around them. Fisetin has emerged as one of the most potent natural senolytics — researchers at the Mayo Clinic have called it "the most potent senolytic" among the natural flavonoids they tested.
Standard curcumin is almost impossible for your body to absorb. We solved this with liposomal delivery — the curcumin is wrapped in a phospholipid layer that protects it through digestion and delivers it to your cells intact. Our liposomal curcumin tests at 67% curcumin content (671 mg/g), with the remaining 33% comprising the phospholipid delivery system. This is a significantly higher curcumin concentration than most liposomal products on the market.
Piperine inhibits the enzymes in your gut that would otherwise break down curcumin before it reaches your bloodstream. Published research suggests piperine can increase curcumin bioavailability by up to 2,000%. But piperine's absorption-enhancing effects aren't limited to curcumin — it also supports the bioavailability of other plant compounds in the formula. It's the quiet multiplier that makes the entire stack work harder.
| Spec | Detail |
|---|---|
| Total active compounds per serving | 1,310mg (2 capsules) |
| Trans-Resveratrol | 500mg (99% from Polygonum Cuspidatum) |
| Quercetin Dihydrate | 200mg (from Sophora Japonica) |
| Fisetin | 100mg (from Cotinus Coggygria) |
| Liposomal Curcumin | 500mg (from Curcuma Longa L.) |
| Piperine | 10mg (from Piper Nigrum) |
| Capsule type | Vegan pullulan (plant-based) |
| Capsules per bottle | 60 |
| Servings per bottle | 30 (at standard dose) |
| Other ingredients | None — zero fillers, zero flow agents |
| Lab testing | Third-party, ISO/IEC 17025:2017 accredited (MS Bioanalytical) |
| Origin | Formulated and packaged in Switzerland |
As you age, some of your cells enter a state called senescence. They stop dividing, but they don't die. They just sit there — taking up space, consuming resources, and secreting inflammatory signals that affect the healthy cells around them.
Scientists have started calling these "zombie cells," and it's a useful metaphor. They're not alive in any productive sense, but they're not dead either. And they accumulate. By middle age, senescent cells represent a growing proportion of your cellular population — and research increasingly links their accumulation to many aspects of ageing.
A senolytic is any compound that selectively targets senescent cells and helps your body clear them. It's not about killing healthy cells — it's about removing the ones that have already stopped working and are actively causing problems. Fisetin has emerged as one of the most promising natural senolytics.
At 100mg per serving (200mg at the full protocol dose), the fisetin in Resveratrol PLUS provides meaningful senolytic support — something you won't find in a standard resveratrol or curcumin supplement.
It doesn't just protect your cells. It helps clear out the ones that are doing more harm than good.
Polyphenols are protective compounds — they work by supporting your body's natural defence and recovery systems rather than producing an immediate, stimulant-like effect. Here's what most people experience, with honest caveats.
Polyphenol supplements work quietly. You're more likely to notice what doesn't happen (the stiffness that didn't show up, the recovery that didn't take as long) than to feel a dramatic "before and after" moment. Some of our most satisfied long-term customers describe it exactly this way — they didn't fully appreciate the difference until they stopped taking it for a few weeks.
Resveratrol PLUS has a small but growing review base across Judge.me and Loox — and every single review to date is 5 stars. We're including all of them because real beats curated.
We make three polyphenol-focused supplements. They're not interchangeable — each serves a different purpose depending on your goals, budget, and where you are in your longevity protocol.
| Resveratrol PLUS | Resveratrol + Quercetin | Pterostilbene Extreme | |
|---|---|---|---|
| What it is | 5-compound synergistic polyphenol + senolytic stack | Classic 2-compound polyphenol pairing | Resveratrol's more bioavailable cousin + grape seed |
| Active compounds | Trans-resveratrol, quercetin, fisetin, liposomal curcumin, piperine | Trans-resveratrol, quercetin | Trans-pterostilbene, organic grape seed extract |
| Total per serving | 1,310mg | 700mg | 200mg |
| Senolytic activity | ✅ Yes (fisetin) | ❌ No | ❌ No |
| Anti-inflammatory | ✅ Yes (liposomal curcumin, 500mg) | ❌ No dedicated compound | ❌ No |
| Absorption enhancement | ✅ Piperine + quercetin synergy + liposomal delivery | ✅ Quercetin enhances resveratrol | ✅ 4× more bioavailable than resveratrol by nature |
| Price | €84.95 (60 caps) | €54.95 (60 caps) | €34.95 (90 caps) |
| Per-day cost | €2.83 (standard) / €5.66 (full protocol) | €1.83 | €0.39 (standard) |
| Best for | People who want comprehensive polyphenol + senolytic coverage in one product | People who want a proven, simpler polyphenol formula at a moderate price | People who want maximum absorption per mg, or an affordable add-on |
Resveratrol PLUS is the comprehensive option — with senolytic activity, anti-inflammatory support, and absorption enhancement built in. It replaces the need to buy separate resveratrol, curcumin, and fisetin supplements.
Resveratrol + Quercetin is the proven classic at €30 less per bottle. You still get the core SIRT1 activation benefit without the senolytic or anti-inflammatory components.
Pterostilbene Extreme delivers superior absorption at €34.95 for a 90-day supply. Great as a standalone or as an affordable add-on to an existing stack.
Resveratrol PLUS + Pterostilbene Extreme gives you five different polyphenols plus pterostilbene's superior blood-brain barrier penetration — two different stilbenes, two different absorption profiles, maximum coverage.
Resveratrol PLUS covers antioxidant protection, senolytic clearance, and anti-inflammatory support. But a comprehensive longevity protocol addresses more than polyphenol pathways. Here's how it fits with the rest of the Nutriop range.
Because it's five products in one. If you bought trans-resveratrol, quercetin, fisetin, liposomal curcumin, and piperine separately, you'd spend significantly more — and you'd be taking five different supplements. The liposomal curcumin alone accounts for a meaningful portion of the cost, because liposomal delivery is genuinely more expensive to produce. And fisetin (from Cotinus Coggygria, not a cheap source) adds senolytic activity no other product in our range provides. If budget is the priority, Pterostilbene Extreme (€34.95 for 90 days) or Resveratrol + Quercetin (€54.95) are solid alternatives.
It depends on what you want. If you're taking our Resveratrol + Quercetin formula, you're getting the core SIRT1 activation benefit. The PLUS version adds three things: fisetin for senolytic support, liposomal curcumin for targeted antioxidant and anti-inflammatory support, and piperine to boost absorption across the board. If those additional pathways matter to you — particularly the senolytic angle — the upgrade makes sense. If you're happy with the simpler formula, there's no pressure to change.
A serving is 2 capsules (1,310mg). The Daily Protocol card recommends 4 capsules daily (2 with breakfast + 2 with dinner) for the full 2,620mg protocol — which aligns with published research dosing. At the full protocol, one bottle lasts 15 days. At the standard 2-capsule dose, one bottle lasts 30 days. We recommend starting at the standard dose and increasing once you're comfortable. Subscribers at the full protocol may want to order two bottles per month.
Standard curcumin has extremely poor bioavailability — less than 1% makes it into your bloodstream. Liposomal delivery wraps the curcumin in a phospholipid layer that protects it through digestion. The 500mg liposomal curcumin contains 67% actual curcumin (the rest is the delivery system) — but the amount that actually reaches your cells is dramatically higher than if we'd used 500mg of standard curcumin.
Not only can you — it's one of the most well-supported combinations in longevity science. Resveratrol activates SIRT1. But SIRT1 requires NAD+ to function. NMN provides the NAD+. Taking both means SIRT1 gets activated (by resveratrol) and fuelled (by NAD+ from NMN). Many longevity researchers include both a polyphenol and an NAD+ precursor in their personal protocols for exactly this reason.
Most customers report noticing a difference within 3–6 weeks of consistent use. The earliest signs tend to be improved recovery from physical activity and a general sense of reduced stiffness. The senolytic benefits build more gradually. We offer a 90-day guarantee specifically because some supplements need time to demonstrate their full effect.
All five ingredients have established safety profiles at the doses used. Resveratrol and quercetin have been studied in humans for decades. Fisetin occurs naturally in fruits and has a clean safety record. Curcumin is one of the most-studied dietary compounds in existence. Piperine at 10mg is well within normal dietary intake. As with any supplement, consult your doctor if you're on medication — particularly blood thinners, as resveratrol and curcumin may have anticoagulant properties.
Standard dose (30-day supply): 2 capsules once daily with food = 1,310mg of synergistic polyphenols. Full protocol (15-day supply): 2 capsules with breakfast + 2 capsules with dinner = 2,620mg daily. At the full protocol, consider subscribing with two bottles per month.
Try Resveratrol PLUS for up to three months. If you don't feel a meaningful difference — in your recovery, your daily comfort, or how your body handles physical effort — email us for a full refund. No hassle.
Take with food — the polyphenols in this formula absorb best alongside a meal, especially one that contains some healthy fats. The piperine enhances absorption regardless, but food helps further.
When: The Daily Protocol card recommends splitting between morning and evening meals (2 AM + 2 PM). This provides sustained polyphenol coverage throughout the day rather than one spike in the morning. If you're taking the standard 2-capsule dose, morning with breakfast is the most common choice.
What to expect: Polyphenol supplements work differently from NMN or caffeine — you won't feel a sudden energy boost. The benefits are protective and cumulative. Most people notice improved recovery and reduced stiffness within 3–6 weeks.
Storage: Keep in a cool, dry place. Avoid direct sunlight and temperatures above 25°C. No refrigeration needed.
Resveratrol PLUS contains five active compounds. Four have been independently tested by MS Bioanalytical, an ISO/IEC 17025:2017-accredited laboratory, using HPLC-UV analysis. The fifth (piperine) is currently in testing — certificate expected soon.
| Ingredient | Method | Purity | Result | Lab Date |
|---|---|---|---|---|
| Trans-Resveratrol | HPLC-UV | 98.72% | 987.2 mg/g | July 2025 |
| Quercetin | HPLC-UV | 97.42% | 974.2 mg/g | July 2025 |
| Fisetin | HPLC-UV | 98.8% | 988.3 mg/g | October 2025 |
| Liposomal Curcumin | HPLC-UV | 67% content* | 671 mg/g | October 2025 |
| Piperine | — | Expected 99%+ | — | Pending |
*Liposomal curcumin tests at 67% curcumin content because the remaining 33% comprises the phospholipid delivery system that enhances absorption. This is not a purity issue — it's by design. Peak area purity is 100%.
SIRT1 activation, senolytic clearance, antioxidant protection, anti-inflammatory support, and absorption enhancement. They don't just coexist in the same capsule — they make each other work better.
1,310mg per serving. Independently tested at the ingredient level. Formulated and packaged in Switzerland. Backed by a 90-day money-back guarantee and a perfect 5-star review average.
This is the polyphenol formula for people who've done the research and want everything in one bottle.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. Consult a healthcare professional before starting any supplement regimen.
