Boosting NAD+ Metabolism with NMN Supplementation: The Latest Clinical
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Boosting NAD+ Metabolism with NMN Supplementation: The Latest Clinical Trial Results

By Massimo Cerquetti juni 15, 2023

Introduction

In the quest for healthy aging, scientists have been exploring various compounds that can potentially slow down the aging process and improve overall health. One such compound that has garnered significant attention is Nicotinamide Mononucleotide (NMN). NMN is a derivative of vitamin B3 and plays a crucial role in the production of a vital cellular resource called Nicotinamide Adenine Dinucleotide (NAD+). NAD+ is essential for energy production, DNA repair, and various other cellular functions. As we age, the levels of NAD+ in our bodies decline, leading to a decrease in cellular function and contributing to the aging process.

Recently, a groundbreaking study titled "Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial" was published, shedding light on the potential benefits of NMN supplementation in humans. This blog post aims to break down the complex scientific jargon and present the findings of this study in a way that is easy to understand for our readers.

The Study Design

The study was a randomized, double-blind, placebo-controlled trial, which is considered the gold standard in clinical research. It involved 36 healthy male and female participants between the ages of 40 and 65. The participants were randomly assigned to two groups. One group received NMN supplements (125 mg/capsule), while the other group received placebo capsules. The participants were instructed to take one capsule twice a day after meals for a period of 12 weeks.

The Objective

The primary objective of the study was to investigate the effects of long-term NMN supplementation on cardiovascular disease risk factors, including arterial stiffness. Arterial stiffness is a common condition associated with aging and is a significant risk factor for cardiovascular diseases.

The Methodology

Before the study began, the participants underwent a series of tests to assess their overall health. These tests included measurements of BMI (Body Mass Index), blood pressure, blood glucose levels, liver function, lipids, and hormones. The researchers also measured the participants' ABI (Ankle-Brachial Index) and baPWV (brachial-ankle pulse wave velocity), which are indicators of arterial stiffness.

During the study, the researchers monitored the serum concentrations of NAM (Nicotinamide), NMN, and NAD+. These compounds play a crucial role in cellular energy production and overall cellular health.

The Findings

The results of the study were quite promising. The researchers found that long-term NMN supplementation led to significant changes in the participants' NAD+ metabolism. More importantly, they observed a reduction in arterial stiffness in the participants who received NMN supplements compared to those who received the placebo.

These findings suggest that NMN supplementation could potentially improve arterial health and reduce the risk of cardiovascular diseases. However, the researchers noted that further clinical trials are needed to confirm these benefits.

What Does This Mean for You?

The findings of this study are exciting news for anyone interested in healthy aging. They suggest that NMN supplementation could be a potential strategy to improve arterial health and reduce the risk of cardiovascular diseases, which are among the leading causes of death worldwide.

However, it's important to note that while the results of this study are promising, more research is needed to fully understand the effects of NMN supplementation in humans. As always, it's recommended to consult with a healthcare professional before starting any new supplement regimen.

Side Effects and Safety

One of the key aspects of any clinical trial is the assessment of safety and potential side effects. In this study, the researchers paid close attention to the health of the participants throughout the trial. The good news is that no serious adverse effects were reported during the study. This is consistent with previous research on NMN, which has generally found it to be safe and well-tolerated.

However, it's important to note that while NMN appears to be safe based on the current evidence, everyone is unique and may react differently to supplements. Therefore, it's always recommended to consult with a healthcare professional before starting any new supplement regimen.

Conclusion

The quest for healthy aging continues, and NMN appears to be a promising candidate in this journey. The latest human trials provide valuable insights into the potential benefits of NMN supplementation, suggesting it could improve arterial health and reduce the risk of cardiovascular diseases. However, more research is needed to fully understand the effects of NMN supplementation in humans. As always, it's recommended to consult with a healthcare professional before starting any new supplement regimen.

In the end, the journey to healthy aging is not just about taking the right supplements. It's also about maintaining a healthy lifestyle that includes a balanced diet, regular exercise, adequate sleep, and stress management. So, while NMN could potentially be a powerful tool in our anti-aging arsenal, it's just one piece of the puzzle.

Stay tuned to our blog for more updates on the latest research in the field of healthy aging and wellness. Here's to living a long, healthy, and fulfilling life!


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1 comment


  • I like Nutriop Longeveti

    Rory on

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