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Sugar's Dark Side: How Glycolysis Fuels Cancer Beyond the 'Two-Hit' Theory
01. The Paradigm of Tumor Suppression Knudson's "Two-Hit" Paradigm Explained Understanding the Original "Two-Hit" HypothesisIn 1971, Alfred Knudson proposed the groundbreaking "two-hit" hypothesis to explain the development of hereditary retinoblastoma, a rare form of childhood eye cancer. According to this hypothesis, two successive genetic "hits" or mutations were necessary to...